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Cardinals vs Lions Prediction

NFL · 11 Oct 2026 · 20:25 UTC · Result: Won (21–45)

🏈NFL
Oct 11 · 8:25 PM UTC
CardinalsVSLions
Moneyline
Lions to Win
ODDS
1.36
Bookie: 74%
🔒 Confidence & value ratingsStarter+
AI ANALYSIS

"The market and the independent model agree closely: 31.9% and 32.9% for Arizona. That leaves no model gap. The Lions are 2-2 and the Cardinals are 1-3. Detroit's offense has been strong, averaging 31.0 points per game through three games against 21.0 for Arizona. St. Brown has 5 touchdowns. Detroit's defense is a weakness, allowing 117 points in four games, the fourth most in the league. Arizona has been worse on defense, allowing 127 points, the second most, and 1,695 total yards, the most. The confirmed news is on the Cardinals' offensive line. Paris Johnson Jr. is out for the season, and Isaiah Adams is likely to miss the game. That weakens Arizona's ability to keep pace in a game with a total of about 53 points. The Lions have won 5 of the last 6 meetings without a loss. The price largely reflects this already, and the Lions are about 5.5-point favorites. I see only a small edge, from the line injuries. The Lions' defensive issues and road travel keep this from being a strong value spot."

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Match preview

Cardinals host Lions in the NFL on 11 Oct 2026, kick-off 20:25 UTC. Recent form: Cardinals 1-3 (season record); Lions 2-2 (season record).

Vantip's record in NFL

  • NFL: 24 wins, 27 losses (47% win rate, voids excluded).
  • Moneyline market across all NFL: 25 wins, 29 losses (46% win rate).

Every settled tip is public on the track record.

Form & Head-to-Head
Cardinals
WLLLL
Lions
WWLWW
Cardinals — last 5
18 OctRams16 - 18Cardinals
11 OctCardinals21 - 45Lions
04 OctGiants36 - 24Cardinals
27 Sept49ers36 - 30Cardinals
20 SeptCardinals7 - 31Seahawks
Lions — last 5
11 OctCardinals21 - 45Lions
27 SeptLions31 - 24Jets
18 SeptBills41 - 31Lions
13 SeptLions31 - 30Saints
29 AugColts16 - 25Lions
Head-to-head — last 4
11 OctCardinals21 - 45Lions
22 SeptCardinals13 - 20Lions
19 DecLions30 - 12Cardinals
27 SeptCardinals23 - 26Lions
Form data via Highlightly. Recent results only; not a prediction.

AI Match Analysis

The market and the independent model agree closely: 31.9% and 32.9% for Arizona. That leaves no model gap. The Lions are 2-2 and the Cardinals are 1-3. Detroit's offense has been strong, averaging 31.0 points per game through three games against 21.0 for Arizona. St. Brown has 5 touchdowns. Detroit's defense is a weakness, allowing 117 points in four games, the fourth most in the league. Arizona has been worse on defense, allowing 127 points, the second most, and 1,695 total yards, the most. The confirmed news is on the Cardinals' offensive line. Paris Johnson Jr. is out for the season, and Isaiah Adams is likely to miss the game. That weakens Arizona's ability to keep pace in a game with a total of about 53 points. The Lions have won 5 of the last 6 meetings without a loss. The price largely reflects this already, and the Lions are about 5.5-point favorites. I see only a small edge, from the line injuries. The Lions' defensive issues and road travel keep this from being a strong value spot.

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